Dr. Randy Proffitt, MD, F.A.C.S

Botox

Click for General Information on: BOTOX®
What are Glabellar Lines?
Glabellar lines are the wrinkles between the brows caused by the contraction of corrugator and/or procerus muscles.
"BOTOX® Cosmetic is now FDA approved to treat Glabellar Lines"

How are Glabellar Lines formed?
BOTOX® Cosmetic is injected directly into the corrugator and procerus muscles, where it enters the nerve endings to block the release of acetylcholine, the chemical that causes muscles to contract.1 Once the muscles are at rest, the skin becomes smoother, creating a more natural and relaxed appearance.

In a clinical study with BOTOX® Cosmetic, the majority of patients (82.5%) reported an improvement in glabellar lines after a week. Results were still reported up to 4 months later.1,2

Performed in the office, the simple, safe procedure takes about 10 minutes. Since the procedure is nonsurgical, no recovery time is needed. After BOTOX® Cosmetic treatment, your patients can get back to work or other activities right away.

Allergan’s BOTOX® product is the only one of its type with over 10 years of successful clinical experience in therapeutic conditions.3 With dosing specific to treat frown lines, this same product is now marketed as BOTOX® Cosmetic.

The most common side effects following the use of BOTOX® Cosmetic for glabellar lines are headache (13.3%), respiratory infection (3.5%), temporary eyelid droop (3.2%), nausea (3.0%), and flu syndrome (2.0%). Blepharoptosis is consistent with the pharmacologic action of BOTOX® Cosmetic and may be technique related.

Less frequently occurring (<3%) adverse reactions included pain in the face, erythema at the injection site, and muscle weakness. These events are thought to be associated with the injection and occurred within the first week.1

BOTOX® Cosmetic is contraindicated in the presence of infection at the proposed injection site(s) and in individuals with known hypersensitivity to any ingredient in the formulation. Do not exceed the recommended dosage and frequency of administration of BOTOX® Cosmetic. Patients with neuromuscular disorders may be at increased risk of clinically significant systemic effects including severe dysphagia and respiratory compromise from typical doses of BOTOX® Cosmetic.

Treatment with BOTOX® Cosmetic for cosmetic purposes may result in the formation of antibodies that may reduce the effectiveness of subsequent treatments with BOTOX® Cosmetic for glabellar lines or BOTOX® for other indications. However, the potential for antibody formation may be minimized by injecting with the lowest effective dose given with the longest feasible intervals between injections.1

References
    1. BOTOX® Cosmetic Irvine, CA: Allergan, Inc; 2002.
    2. Data on File, Allergan, Inc.
    3. BOTOX® Irvine, CA: Allergan, Inc; 2002.