Dr. Randy Proffitt, MD, F.A.C.S
Click for General Information on:
BOTOX®
What are Glabellar Lines?
Glabellar lines are the wrinkles between the brows caused by the contraction
of corrugator and/or procerus muscles. |
"BOTOX® Cosmetic
is now FDA approved to treat Glabellar Lines" |
How are Glabellar Lines formed?
BOTOX® Cosmetic is injected directly into the corrugator and procerus
muscles, where it enters the nerve endings to block the release of acetylcholine,
the chemical that causes muscles to contract.
1 Once the muscles are
at rest, the skin becomes smoother, creating a more natural and relaxed appearance.
In a clinical study with
BOTOX® Cosmetic, the majority of patients
(82.5%) reported an improvement in glabellar lines after a week. Results were
still reported up to 4 months later.
1,2
Performed in the office, the simple, safe procedure takes about 10 minutes.
Since the procedure is nonsurgical, no recovery time is needed. After
BOTOX®
Cosmetic treatment, your patients can get back to work or other activities
right away.
Allergan’s
BOTOX® product is the only one of its type with over
10 years of successful clinical experience in therapeutic conditions.
3
With dosing specific to treat frown lines, this same product is now marketed
as
BOTOX® Cosmetic.
The most common side effects following the use of
BOTOX® Cosmetic
for glabellar lines are headache (13.3%), respiratory infection (3.5%), temporary
eyelid droop (3.2%), nausea (3.0%), and flu syndrome (2.0%). Blepharoptosis
is consistent with the pharmacologic action of
BOTOX® Cosmetic and
may be technique related.
Less frequently occurring (<3%) adverse reactions included pain in the face,
erythema at the injection site, and muscle weakness. These events are thought
to be associated with the injection and occurred within the first week.
1
BOTOX® Cosmetic is contraindicated in the presence of infection
at the proposed injection site(s) and in individuals with known hypersensitivity
to any ingredient in the formulation. Do not exceed the recommended dosage and
frequency of administration of
BOTOX® Cosmetic. Patients with neuromuscular
disorders may be at increased risk of clinically significant systemic effects
including severe dysphagia and respiratory compromise from typical doses of
BOTOX® Cosmetic.
Treatment with
BOTOX® Cosmetic for cosmetic purposes may result
in the formation of antibodies that may reduce the effectiveness of subsequent
treatments with
BOTOX® Cosmetic for glabellar lines or
BOTOX®
for other indications. However, the potential for antibody formation may
be minimized by injecting with the lowest effective dose given with the longest
feasible intervals between injections.
1
References
- BOTOX® Cosmetic Irvine, CA: Allergan, Inc; 2002.
- Data on File, Allergan, Inc.
- BOTOX® Irvine, CA: Allergan, Inc; 2002.